Koumbalones a and b, new casbane diterpenes from maprounea africana

Yoel Kashman, Matthew W. Bernart*, Mark TischLer, John H. Cardellina, Michael R. Boyd

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The organic extract of Maprounea africana yielded koumbalones A [1] and B [2], defined by spectral methods as new variations on the casbane ring system. The gross structures, relative configurations, and solution conformations were determined by a combination of spectral analyses and molecular modeling. Because koumbalone A spontaneously converts to koumbalone B at room temperature, koumbalone B may be an artifact of isolation.

Original languageEnglish
Pages (from-to)426-430
Number of pages5
JournalJournal of Natural Products
Issue number3
StatePublished - 1 Mar 1994
Externally publishedYes


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