Kinetic and cross-linking studies indicate different receptors for endothelins and sarafotoxins in the ileum and cerebellum

Ronit Galron, Avner Bdolah, Elazar Kochva, Zvi Wollberg, Yoel Kloog, Mordechai Sokolovsky

Research output: Contribution to journalArticlepeer-review

Abstract

Kinetics of ligand/receptor interactions using ET-1, ET-3 and SRTX-b were studied and cross-linking experiments carried out in guinea pig ileum and rat cerebellar preparations. Dissociation studies indicate that the two regions are characterized by different receptor subtypes and different modes of ligand binding. Autoradiographic patterns obtained following cross-linking of ET-1 and ET-3 to the different issues support these conclusions.

Original languageEnglish
Pages (from-to)11-14
Number of pages4
JournalFEBS Letters
Volume283
Issue number1
DOIs
StatePublished - 20 May 1991

Keywords

  • Affinity labeling
  • Brain
  • Endothelin-1
  • Endothelin-3
  • Peripheral
  • Rate of dissociation
  • Receptor subtype
  • Sarafotoxin

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