Kinetic and cross-linking studies indicate different receptors for endothelins and sarafotoxins in the ileum and cerebellum

Ronit Galron; Avner Bdolah; Elazar Kochva; Zvi Wollberg; Yoel Kloog; Mordechai Sokolovsky

doi:10.1016/0014-5793(91)80542-B

Kinetic and cross-linking studies indicate different receptors for endothelins and sarafotoxins in the ileum and cerebellum

Ronit Galron, Avner Bdolah, Elazar Kochva, Zvi Wollberg, Yoel Kloog, Mordechai Sokolovsky^*

^*Corresponding author for this work

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Kinetics of ligand/receptor interactions using ET-1, ET-3 and SRTX-b were studied and cross-linking experiments carried out in guinea pig ileum and rat cerebellar preparations. Dissociation studies indicate that the two regions are characterized by different receptor subtypes and different modes of ligand binding. Autoradiographic patterns obtained following cross-linking of ET-1 and ET-3 to the different issues support these conclusions.

Original language	English
Pages (from-to)	11-14
Number of pages	4
Journal	FEBS Letters
Volume	283
Issue number	1
DOIs	https://doi.org/10.1016/0014-5793(91)80542-B
State	Published - 20 May 1991

Keywords

Affinity labeling
Brain
Endothelin-1
Endothelin-3
Peripheral
Rate of dissociation
Receptor subtype
Sarafotoxin

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10.1016/0014-5793(91)80542-B

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title = "Kinetic and cross-linking studies indicate different receptors for endothelins and sarafotoxins in the ileum and cerebellum",

abstract = "Kinetics of ligand/receptor interactions using ET-1, ET-3 and SRTX-b were studied and cross-linking experiments carried out in guinea pig ileum and rat cerebellar preparations. Dissociation studies indicate that the two regions are characterized by different receptor subtypes and different modes of ligand binding. Autoradiographic patterns obtained following cross-linking of ET-1 and ET-3 to the different issues support these conclusions.",

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AU - Galron, Ronit

AU - Bdolah, Avner

AU - Kochva, Elazar

AU - Wollberg, Zvi

AU - Kloog, Yoel

AU - Sokolovsky, Mordechai

PY - 1991/5/20

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AB - Kinetics of ligand/receptor interactions using ET-1, ET-3 and SRTX-b were studied and cross-linking experiments carried out in guinea pig ileum and rat cerebellar preparations. Dissociation studies indicate that the two regions are characterized by different receptor subtypes and different modes of ligand binding. Autoradiographic patterns obtained following cross-linking of ET-1 and ET-3 to the different issues support these conclusions.

KW - Affinity labeling

KW - Brain

KW - Endothelin-1

KW - Endothelin-3

KW - Peripheral

KW - Rate of dissociation

KW - Receptor subtype

KW - Sarafotoxin

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Kinetic and cross-linking studies indicate different receptors for endothelins and sarafotoxins in the ileum and cerebellum

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Keywords

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