TY - JOUR
T1 - Kidney-derived urinary antigens assayed with monoclonal antibodies for the detection of renal damage
AU - Falkenberg, Frank W.
AU - Mai, Uwe
AU - Puppe, Christine
AU - Risse, Peter
AU - Herrmann, Gabriele
AU - Hecking, Erwin
AU - Bremer, Karl
AU - Mondorf, A. Werner
AU - Shapira, Z.
N1 - Funding Information:
This work was supported by grants Fa71/10-5 of the Deutsche For-schungsgemeinschaftu nd I/36 986 of the Stiftung Volkswagenwerk.
PY - 1986/10/31
Y1 - 1986/10/31
N2 - For the quantitation of kidney-derived Urinary Antigens (UA) monoclonal antibodies specific for antigens localized in cells of defined subunits of the nephron were applied in sandwich ELISA. Antigen excretion was measured in the urine of healthy individuals, patients suffering from various diseases, kidney transplant recipients, and healthy volunteers receiving therapeutic doses of antibiotic drugs. In healthy individuals, in patients with diseases primarily affecting the glomerulus, and in inactive phases of chronic diseases antigen excretion was low. Toxic drug effects enhanced antigenuria. Excretion of some or all of the antigens always indicated tubular alterations. The tests thus provide information on location and extent of acute primary tubular damage.
AB - For the quantitation of kidney-derived Urinary Antigens (UA) monoclonal antibodies specific for antigens localized in cells of defined subunits of the nephron were applied in sandwich ELISA. Antigen excretion was measured in the urine of healthy individuals, patients suffering from various diseases, kidney transplant recipients, and healthy volunteers receiving therapeutic doses of antibiotic drugs. In healthy individuals, in patients with diseases primarily affecting the glomerulus, and in inactive phases of chronic diseases antigen excretion was low. Toxic drug effects enhanced antigenuria. Excretion of some or all of the antigens always indicated tubular alterations. The tests thus provide information on location and extent of acute primary tubular damage.
KW - Determination of kidney alteration and damage
KW - Kidney-derived urinary antigens
UR - http://www.scopus.com/inward/record.url?scp=0022967743&partnerID=8YFLogxK
U2 - 10.1016/0009-8981(86)90139-7
DO - 10.1016/0009-8981(86)90139-7
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AN - SCOPUS:0022967743
SN - 0009-8981
VL - 160
SP - 171
EP - 182
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
IS - 2
ER -
