Ketotifen is protective against indomethacin-induced intestinal ulceration in the rat

I. Zahavi, T. Weizen, H. Marcus, F. Karmeli, G. Dinari*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Ketotifen is an anti-allergic agent that was recently shown to prevent experimental gastric and colonic mucosal injury. We studied the effect of ketotifen on indomethacin-induced small intestinal ulceration in the rat. Ulceration was produced by s.c. injection of 30 mg/kg indomethacin, 30 min after refeeding 24 h fasted rats. Total ulcer area (mm2), prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) were measured 24 h after indomethacin administration. Study groups received ketotifen 100 μg/100 g body weight 30 min before and 5 h after indomethacin administration, either i.p. or orally. There were 7-9 animals in each group. Ulcer area was significantly reduced by oral administration of ketotifen from 229 ± 26 to 146 ± 28 mm2. PGE2 level was reduced by ketotifen from 505 ± 73 to 228 ± 68 ng/mg protein, and LTB4, was reduced from 289 ± 68 to 59 ± 26 ng/mg protein. Intraperitoneal administration of ketotifen had no effect on any of the measured parameters. Ketotifen had a definite protective effect on small intestinal mucosa in the rat, which was accompanied by a reduction of mucosal inflammatory mediators. Ketotifen may have a role in tile prevention or treatment of small intestinal damage induced by nonsteroidal anti-inflammatory drugs.

Original languageEnglish
Pages (from-to)312-315
Number of pages4
JournalIsrael Journal of Medical Sciences
Issue number5
StatePublished - May 1996
Externally publishedYes


  • Indomethacin
  • Ketotifen
  • Leukotriene B
  • NSAIDs
  • Prostaglandin E
  • Small intestinal damage


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