TY - JOUR
T1 - Kaposi's sarcoma among AIDS patients
T2 - Transmissible venereal tumour by cell engraftment?
AU - Rechavi, G.
AU - Katzir, N.
AU - Ramot, B.
N1 - Funding Information:
B.R. is incumbent of the Gregorio and Dora Shapiro Chair for Haematologic Malignancies, Sackler School of Medicine, Tel Aviv University. This work is supported in part by The Irwin Edelstein Leukemia Research Fund, The Freda and Moise Es-kenazy Fund for Cancer Research and The Ruth Blumenthal Foundation for Cancer Research.
PY - 1991/4
Y1 - 1991/4
N2 - The epidemiologic findings of Kaposi's sarcoma (KS) among patients with the acquired immunodeficiency syndrome (AIDS) suggest that human immunodeficiency virus (HIV) infection is insufficient for the development of KS. It was speculated that another sexually transmitted infection is responsible for the markedly increased incidence of KS among patients who acquired HIV infection through sexual intercourse. However, no such contributing infectious agent was consistently identified. The canine transmissible venereal tumour (TVT) is a malignant tumour that can be transplanted by viable cells across major histocompatibility complex (MHC) barriers. Recent findings suggest that all canine TVTs originated from the same tumour and were transferred from one animal to the other during sexual intercourse. It is suggested that, in analogy with the canine TVT model, the characteristics of KS epidemic among AIDS patients may be explained by transmission and engraftment of viable malignant cells during intercourse.
AB - The epidemiologic findings of Kaposi's sarcoma (KS) among patients with the acquired immunodeficiency syndrome (AIDS) suggest that human immunodeficiency virus (HIV) infection is insufficient for the development of KS. It was speculated that another sexually transmitted infection is responsible for the markedly increased incidence of KS among patients who acquired HIV infection through sexual intercourse. However, no such contributing infectious agent was consistently identified. The canine transmissible venereal tumour (TVT) is a malignant tumour that can be transplanted by viable cells across major histocompatibility complex (MHC) barriers. Recent findings suggest that all canine TVTs originated from the same tumour and were transferred from one animal to the other during sexual intercourse. It is suggested that, in analogy with the canine TVT model, the characteristics of KS epidemic among AIDS patients may be explained by transmission and engraftment of viable malignant cells during intercourse.
UR - http://www.scopus.com/inward/record.url?scp=0025753523&partnerID=8YFLogxK
U2 - 10.1016/0306-9877(91)90051-Y
DO - 10.1016/0306-9877(91)90051-Y
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AN - SCOPUS:0025753523
SN - 0306-9877
VL - 34
SP - 338
EP - 341
JO - Medical Hypotheses
JF - Medical Hypotheses
IS - 4
ER -