Joint and entheseal inflammation in the knee region in spondyloarthritis - reliability and responsiveness of two OMERACT whole-body MRI scores

Marie Wetterslev*, Walter P. Maksymowych, Robert GW Lambert, Iris Eshed, Susanne J. Pedersen, Maria S. Stoenoiu, Simon Krabbe, Paul Bird, Violaine Foltz, Ashish J. Mathew, Frédérique Gandjbakhch, Joel Paschke, Philippe Carron, Gabriele De Marco, Helena Marzo-Ortega, Anna EF Poulsen, Jacob L. Jaremko, Philip G. Conaghan, Mikkel Østergaard

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To perform region-based development of whole-body MRI through validation of knee region scoring systems in spondyloarthritis (SpA). Methods: Assessment of knee inflammatory pathologies using 2 systems, OMERACT MRI Whole-body score for Inflammation in Peripheral joints and Entheses (MRI-WIPE) and Knee Inflammation MRI Scoring System (KIMRISS), in 4 iterative multi-reader exercises. Results: In the final exercise, reliability was mostly good for readers with highest agreement in previous exercise. Median pairwise single-measure ICCs for osteitis and synovitis/effusion status/change were 0.71/0.48 (WIPE-osteitis), 0.48/0.77 (WIPE-synovitis/effusion), 0.59/0.91 (KIMRISS-osteitis) and 0.92/0.97 (KIMRISS-synovitis/effusion). SRMs were 0.74 (WIPE-synovitis/effusion) and 0.78 (KIMRISS-synovitis/effusion). Conclusion: MRI-WIPE and KIMRISS may both be useful in SpA whole-body evaluation studies.

Original languageEnglish
Pages (from-to)933-939
Number of pages7
JournalSeminars in Arthritis and Rheumatism
Volume51
Issue number4
DOIs
StatePublished - Aug 2021

Keywords

  • KIMRISS
  • Knee
  • MRI-WIPE
  • OMERACT
  • Spondyloarthritis
  • Whole-body MRI

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