Job-splitting among integrins

Ronen Zaidel-Bar

doi:10.1038/ncb2770

Job-splitting among integrins

Ronen Zaidel-Bar^*

^*Corresponding author for this work

National University of Singapore

Research output: Contribution to journal › Comment/debate

7 Scopus citations

Abstract

How different integrin receptors for the same extracellular ligand transduce distinct cellular responses is unclear. The characterization of the class-specific adhesomes of β 1 and α V integrins now shows that whereas α V integrins promote unbranched actin polymerization, β 1 integrins induce myosin-II-dependent contractility, and both integrin subtypes synergistically mediate rigidity sensing.

Original language	English
Pages (from-to)	575-577
Number of pages	3
Journal	Nature Cell Biology
Volume	15
Issue number	6
DOIs	https://doi.org/10.1038/ncb2770
State	Published - Jun 2013
Externally published	Yes

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Job-splitting among integrins

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