Job-splitting among integrins

Research output: Contribution to journalComment/debate

Abstract

How different integrin receptors for the same extracellular ligand transduce distinct cellular responses is unclear. The characterization of the class-specific adhesomes of β 1 and α V integrins now shows that whereas α V integrins promote unbranched actin polymerization, β 1 integrins induce myosin-II-dependent contractility, and both integrin subtypes synergistically mediate rigidity sensing.

Original languageEnglish
Pages (from-to)575-577
Number of pages3
JournalNature Cell Biology
Volume15
Issue number6
DOIs
StatePublished - Jun 2013
Externally publishedYes

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