Jellyfish smart wound dressing device containing in-situ synthesized anti-bacterial nanoparticles

Roman Nudelman, Hashim Alhmoud, Bahman Delalat, Roey Elnathan, Tammila Guliakhmedova, Michael Gozin, Shachar Richter, Nicolas Voelcker

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


Although the negative consequences of the global phenomenon of jellyfish (JF) swarms are
well recognized, the use of their biomass for practical applications is mostly limited to a
niche in the Asian food industry. This fact is quite surprising since JF’ biomass is comprised
of useful biomaterials such as Q-mucin glycoprotein and collagen. In this work, we utilized
the jellyfish biomass, collected from two different species, to prepare electrospun scaffolds
composed of nanometric “core-shell”-type fibers, in which adjustment of the electrospinning
process parameters can easily control their mechanical, morphological and chemical
properties. This non-woven scaffold shows excellent biocompatibility and biodegradability,
indicating suitability for biomedical research contexts. Performed cell proliferation assays
showed that the scaffold could support the growth of cardiac cells, fitting requirement of
tissue engineering. Additional incorporation of in situ-generated silver nanoparticles in these
nanofibers produced mats with potent antibacterial properties. Preclinical trials with the
resulted mats on porcine wound healing model exhibited fast and complete healing of
Original languageEnglish
Title of host publicationInternational Conference on Nanostructured Materials (NANO 2020)
Place of PublicationMelbourne
PublisherEngineers Australia Pty. Ltd.
ISBN (Print)9781925627510
StatePublished - Jan 2020


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