TY - JOUR
T1 - Jejunal Inflammation in Crohn's Disease
T2 - Comparison Between Diffusion Weighted Magnetic Resonance Imaging and Video Capsule Endoscopy
AU - Amitai, Michal M.
AU - Kanaan, Nadin
AU - Soffer, Shelly
AU - Alper, Lee
AU - Rozendorn, Noa
AU - Harrington, Daniel Jacob
AU - Kopylov, Uri
AU - Lahat, Adi
AU - Yablecovitch, Doron
AU - Eliakim, Rami
AU - Ben-Horin, Shomron
AU - Klang, Eyal
N1 - Publisher Copyright:
© 2023 Israel Medical Association. All rights reserved.
PY - 2023/8
Y1 - 2023/8
N2 - Background: Jejunal disease is associated with worse prognosis in Crohn's disease. The added value of diffusion weighted imaging for evaluating jejunal inflammation related to Crohn's Disease is scarce. Objectives: To compare diffusion weighted imaging, video capsule endoscopy, and inflammatory biomarkers in the assessment of Crohn's disease involving the jejunum. Methods: Crohn's disease patients in clinical remission were prospectively recruited and underwent magnetic resonance (MR)-enterography and video capsule endoscopy. C-reactive protein and fecal-calprotectin levels were obtained. MR-en-terography images were evaluated for restricted diffusion, and apparent diffusion coefficient values were measured. The video capsule endoscopy-based Lewis score was calculated. Associations between diffusion weighted imaging, apparent diffusion coefficient, Lewis score, and inflammatory biomarkers were evaluated. Results: The study included 51 patients, and 27/51 (52.9%) with video capsule endoscopies showed jejunal mucosal inflammation. Sensitivity and specificity of restricted diffusion for video capsule endoscopy mucosal inflammation were 59.3% and 37.5% for the first reader, and 66.7% and 37.5% for the second reader, respectively. Diffusion weighted imaging was not statistically associated with jejunal video capsule endoscopy inflammation (P= 0.813). Conclusions: Diffusion weighted imaging was not an effective test for evaluation of jejunal inflammation as seen by video capsule endoscopy in patients with quiescent Crohn's disease.
AB - Background: Jejunal disease is associated with worse prognosis in Crohn's disease. The added value of diffusion weighted imaging for evaluating jejunal inflammation related to Crohn's Disease is scarce. Objectives: To compare diffusion weighted imaging, video capsule endoscopy, and inflammatory biomarkers in the assessment of Crohn's disease involving the jejunum. Methods: Crohn's disease patients in clinical remission were prospectively recruited and underwent magnetic resonance (MR)-enterography and video capsule endoscopy. C-reactive protein and fecal-calprotectin levels were obtained. MR-en-terography images were evaluated for restricted diffusion, and apparent diffusion coefficient values were measured. The video capsule endoscopy-based Lewis score was calculated. Associations between diffusion weighted imaging, apparent diffusion coefficient, Lewis score, and inflammatory biomarkers were evaluated. Results: The study included 51 patients, and 27/51 (52.9%) with video capsule endoscopies showed jejunal mucosal inflammation. Sensitivity and specificity of restricted diffusion for video capsule endoscopy mucosal inflammation were 59.3% and 37.5% for the first reader, and 66.7% and 37.5% for the second reader, respectively. Diffusion weighted imaging was not statistically associated with jejunal video capsule endoscopy inflammation (P= 0.813). Conclusions: Diffusion weighted imaging was not an effective test for evaluation of jejunal inflammation as seen by video capsule endoscopy in patients with quiescent Crohn's disease.
KW - diagnosis and imaging
KW - enterography
KW - gastroenterology radiology
KW - inflammatory bowel disease
KW - magnetic resonance
UR - http://www.scopus.com/inward/record.url?scp=85168060582&partnerID=8YFLogxK
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C2 - 37574895
AN - SCOPUS:85168060582
SN - 1565-1088
VL - 25
SP - 559
EP - 563
JO - Israel Medical Association Journal
JF - Israel Medical Association Journal
IS - 8
ER -