It takes three to the DNA damage response tango

Sapir Schlam-Babayov, Yael Ziv, Yosef Shiloh*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The DNA damage response is robustly activated by DNA double-strand breaks and controlled by three apical protein kinases of the PI3-kinase-related protein kinase (PIKK) family: ataxia-telangiectasia, mutated (ATM), ataxia-telangiectasia and Rad3-related (ATR) and DNA-dependent protein kinase (DNA-PK). Phosphoproteomic analysis reveals the relative share of these PIKKs in coordinating this network, and compensation by ATR and DNA-PK for ATM absence in the genetic disorder, ataxia-telangiectasia (A-T).

Original languageEnglish
Article number1881395
JournalMolecular and Cellular Oncology
Issue number2
StatePublished - 2021


  • ATM
  • Ataxia-telangiectasia
  • DNA damage response
  • PIKKs
  • phosphoproteomic


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