It takes three to the DNA damage response tango

Sapir Schlam-Babayov, Yael Ziv, Yosef Shiloh

Research output: Contribution to journalArticlepeer-review

Abstract

The DNA damage response is robustly activated by DNA double-strand breaks and controlled by three apical protein kinases of the PI3-kinase-related protein kinase (PIKK) family: ataxia-telangiectasia, mutated (ATM), ataxia-telangiectasia and Rad3-related (ATR) and DNA-dependent protein kinase (DNA-PK). Phosphoproteomic analysis reveals the relative share of these PIKKs in coordinating this network, and compensation by ATR and DNA-PK for ATM absence in the genetic disorder, ataxia-telangiectasia (A-T).

Original languageEnglish
Article number1881395
JournalMolecular and Cellular Oncology
Volume8
Issue number2
DOIs
StatePublished - 2021

Keywords

  • ATM
  • Ataxia-telangiectasia
  • DNA damage response
  • PIKKs
  • phosphoproteomic

Fingerprint

Dive into the research topics of 'It takes three to the DNA damage response tango'. Together they form a unique fingerprint.

Cite this