TY - JOUR
T1 - It takes three to the DNA damage response tango
AU - Schlam-Babayov, Sapir
AU - Ziv, Yael
AU - Shiloh, Yosef
N1 - Publisher Copyright:
© 2021 Taylor & Francis Group, LLC.
PY - 2021
Y1 - 2021
N2 - The DNA damage response is robustly activated by DNA double-strand breaks and controlled by three apical protein kinases of the PI3-kinase-related protein kinase (PIKK) family: ataxia-telangiectasia, mutated (ATM), ataxia-telangiectasia and Rad3-related (ATR) and DNA-dependent protein kinase (DNA-PK). Phosphoproteomic analysis reveals the relative share of these PIKKs in coordinating this network, and compensation by ATR and DNA-PK for ATM absence in the genetic disorder, ataxia-telangiectasia (A-T).
AB - The DNA damage response is robustly activated by DNA double-strand breaks and controlled by three apical protein kinases of the PI3-kinase-related protein kinase (PIKK) family: ataxia-telangiectasia, mutated (ATM), ataxia-telangiectasia and Rad3-related (ATR) and DNA-dependent protein kinase (DNA-PK). Phosphoproteomic analysis reveals the relative share of these PIKKs in coordinating this network, and compensation by ATR and DNA-PK for ATM absence in the genetic disorder, ataxia-telangiectasia (A-T).
KW - ATM
KW - Ataxia-telangiectasia
KW - DNA damage response
KW - PIKKs
KW - phosphoproteomic
UR - http://www.scopus.com/inward/record.url?scp=85100709662&partnerID=8YFLogxK
U2 - 10.1080/23723556.2021.1881395
DO - 10.1080/23723556.2021.1881395
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C2 - 33860085
AN - SCOPUS:85100709662
SN - 2372-3556
VL - 8
JO - Molecular and Cellular Oncology
JF - Molecular and Cellular Oncology
IS - 2
M1 - 1881395
ER -
