It takes three to the DNA damage response tango

Sapir Schlam-Babayov, Yael Ziv, Yosef Shiloh*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The DNA damage response is robustly activated by DNA double-strand breaks and controlled by three apical protein kinases of the PI3-kinase-related protein kinase (PIKK) family: ataxia-telangiectasia, mutated (ATM), ataxia-telangiectasia and Rad3-related (ATR) and DNA-dependent protein kinase (DNA-PK). Phosphoproteomic analysis reveals the relative share of these PIKKs in coordinating this network, and compensation by ATR and DNA-PK for ATM absence in the genetic disorder, ataxia-telangiectasia (A-T).

Original languageEnglish
Article number1881395
JournalMolecular and Cellular Oncology
Volume8
Issue number2
DOIs
StatePublished - 2021

Funding

FundersFunder number
Naomi Prawer Kadar Foundation
Israel Cancer Research Fund
Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung31003A 166435
Tel Aviv University
SystemsX.ch

    Keywords

    • ATM
    • Ataxia-telangiectasia
    • DNA damage response
    • PIKKs
    • phosphoproteomic

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