It takes a village to grow leukemia

Sarah Elitzur, Shai Izraeli

Research output: Contribution to journalArticlepeer-review

Abstract

In this issue of Blood, Barz et al identified NT5C2 thiopurine resistance mutations in 16% of children with relapsed B-cell acute lymphoblastic leukemia (B-ALL). Despite the fact that most of the mutations were subclonal, their presence was associated with an inferior outcome. Strikingly, NT5C2-mutated cells were sensitive to relapse therapy, suggesting a complex association between NT5C2 mutations and the poor prognosis of relapsed ALL.

Original languageEnglish
Pages (from-to)886-887
Number of pages2
JournalBlood
Volume135
Issue number12
DOIs
StatePublished - 19 Mar 2020
Externally publishedYes

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