Isoprenoids of the soft coral Sarcophyton glaucum: Nyalolide, a new biscembranoid, and other terpenoids

Moran Feller, Amira Rudi, Nelly Berer, Israel Goldberg, Zafra Stein, Yehuda Benayahu, Michael Schleyer, Yoel Kashman

Research output: Contribution to journalArticlepeer-review

Abstract

The chemical content of Sarcophyton glaucum, one of the more abundant soft corals on many coral reefs, collected from many seas, was thoroughly explored, resulting in the discovery of a large number of cembranoids, biscembranoids, sterols, and other secondary metabolites. The presently investigated Kenyan specimens of S. glaucum yielded three new metabolites, i.e., nyalolide (15), a biscembranoid, 16-oxosarcoglaucol acetate (16), a cembranoid, and the sesquiterpene guaiacophine (17). Nyalolide was also isolated from the Kenyan soft coral Sarcophyton elegans. The structures of the new compounds were elucidated by interpretation of their MS and 1D and 2D NMR experiments and, in the case of nyalolide, possessing 11 chiral centers, secured by X-ray diffraction analysis.

Original languageEnglish
Pages (from-to)1303-1308
Number of pages6
JournalJournal of Natural Products
Volume67
Issue number8
DOIs
StatePublished - Aug 2004

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