TY - JOUR
T1 - Isolation and structure elucidation of secondary metabolites from a Microcystis sp. bloom material collected in southern Israel
AU - Hasin, Ohad
AU - Carmeli, Shmuel
N1 - Publisher Copyright:
© Copyright 2018 Natural Product Communciations Inc. All Rights Reserved.
PY - 2018/10
Y1 - 2018/10
N2 - The hydrophilic extract of Microcystis sp. bloom material collected from Bror Hayil Reservoir in southern Israel afforded four new metabolites, (2S,3S)-3- hydeoxy-1,4-diphenylbutan-2-yl-acetate, aeruginosins BH604, BH462A and BH462B, and two known metabolites cyanopeptolins S and SS. The planar structure of 1-4 was established by analyses of their 1D and 2D NMR data and mass spectrometric data. The absolute configurations of the chiral centers of 1 were established by Mosher method and analysis of the coupling constants between H-2 and H-3, and those of 2-4 by Merfay's method and advanced Merfay's method and chiral HPLC. The compounds do not inhibit the serine proteases trypsin and thrombin.
AB - The hydrophilic extract of Microcystis sp. bloom material collected from Bror Hayil Reservoir in southern Israel afforded four new metabolites, (2S,3S)-3- hydeoxy-1,4-diphenylbutan-2-yl-acetate, aeruginosins BH604, BH462A and BH462B, and two known metabolites cyanopeptolins S and SS. The planar structure of 1-4 was established by analyses of their 1D and 2D NMR data and mass spectrometric data. The absolute configurations of the chiral centers of 1 were established by Mosher method and analysis of the coupling constants between H-2 and H-3, and those of 2-4 by Merfay's method and advanced Merfay's method and chiral HPLC. The compounds do not inhibit the serine proteases trypsin and thrombin.
KW - Aeruginosins
KW - Cyanobacteria
KW - Microcystis
KW - Secondary metabolites
UR - http://www.scopus.com/inward/record.url?scp=85055805774&partnerID=8YFLogxK
U2 - 10.1177/1934578x1801301020
DO - 10.1177/1934578x1801301020
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AN - SCOPUS:85055805774
SN - 1934-578X
VL - 13
SP - 1313
EP - 1318
JO - Natural Product Communications
JF - Natural Product Communications
IS - 10
ER -