TY - JOUR
T1 - Isolation and structure elucidation of lobophytosterol, depresosterol and three other closely related sterols. Five new C28 polyoxygenated sterols from the red sea soft coral lobophytum depressum
AU - Carmely, S.
AU - Kashman, Y.
N1 - Funding Information:
Acknowledgemenrs-Wc wish to express our appreciation to Dr. Y. Loya and Mr. Y. Benayahu for collection and identification of the soft coral and the United States-Israel Binational Science Foundation for partial support (Grant 2201/80).
PY - 1981
Y1 - 1981
N2 - A series of polyoxygenated sterols were isolated from the soft coral Lobophytum depressum. The structure of five of these sterols was elucidated and determined to be. 5β,6β - epoxy - 24ξ - methylchloestan -3β, 22(R),25-triol (2a), 22(R),28 - oxido - 24ξ - methylcholest - 5 - en - 3β,25,28 - triol (1c, lobophytosterol), 24ξ -methyl - cholest - 5 22(R),25,28 - tetraol (1b, depresosterol), and 5β,6β - epoxy derivatives of lobophytosterol and depresosterol, Tcompounds 2c and 2b respectively. The structures were determined mainly on the basis of the fully interpreted 1H and 13C NMR spectra as well as the mass spectrum and several chemical transformations which resulted in unambiguous structures. All identified compounds belong to the C28 category and are the first examples of marine sterols possessing the C28-atom in various oxidative states.
AB - A series of polyoxygenated sterols were isolated from the soft coral Lobophytum depressum. The structure of five of these sterols was elucidated and determined to be. 5β,6β - epoxy - 24ξ - methylchloestan -3β, 22(R),25-triol (2a), 22(R),28 - oxido - 24ξ - methylcholest - 5 - en - 3β,25,28 - triol (1c, lobophytosterol), 24ξ -methyl - cholest - 5 22(R),25,28 - tetraol (1b, depresosterol), and 5β,6β - epoxy derivatives of lobophytosterol and depresosterol, Tcompounds 2c and 2b respectively. The structures were determined mainly on the basis of the fully interpreted 1H and 13C NMR spectra as well as the mass spectrum and several chemical transformations which resulted in unambiguous structures. All identified compounds belong to the C28 category and are the first examples of marine sterols possessing the C28-atom in various oxidative states.
UR - http://www.scopus.com/inward/record.url?scp=0011171545&partnerID=8YFLogxK
U2 - 10.1016/S0040-4020(01)88896-7
DO - 10.1016/S0040-4020(01)88896-7
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AN - SCOPUS:0011171545
VL - 37
SP - 2397
EP - 2403
JO - Tetrahedron
JF - Tetrahedron
SN - 0040-4020
IS - 13
ER -
