TY - JOUR
T1 - Isolation and characterization of novel cytotoxic saponins from Archidendron ellipticum
AU - Beutler, John A.
AU - Kashman, Yoel
AU - Pannell, Lewis K.
AU - Cardellina, John H.
AU - Alexander, Mark R.A.
AU - Balaschak, Michael S.
AU - Prather, Tanya R.
AU - Shoemaker, Robert H.
AU - Boyd, Michael R.
PY - 1997/8
Y1 - 1997/8
N2 - A series of new ester saponins, elliptosides A-J, has been isolated from the tropical plant Archidendron ellipticum (Leguminosae). These saponins were particularly cytotoxic to certain renal and melanoma cancer cell lines in the NCI's 60-cell line human tumor screen. The structures of elliptosides A, E, and F were elucidated by spectroscopic and chemical means. Elliptoside A showed in vivo antitumor activity against the LOX melanoma cell line.
AB - A series of new ester saponins, elliptosides A-J, has been isolated from the tropical plant Archidendron ellipticum (Leguminosae). These saponins were particularly cytotoxic to certain renal and melanoma cancer cell lines in the NCI's 60-cell line human tumor screen. The structures of elliptosides A, E, and F were elucidated by spectroscopic and chemical means. Elliptoside A showed in vivo antitumor activity against the LOX melanoma cell line.
UR - http://www.scopus.com/inward/record.url?scp=0030861507&partnerID=8YFLogxK
U2 - 10.1016/S0968-0896(97)00098-9
DO - 10.1016/S0968-0896(97)00098-9
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AN - SCOPUS:0030861507
VL - 5
SP - 1509
EP - 1517
JO - Bioorganic and Medicinal Chemistry
JF - Bioorganic and Medicinal Chemistry
SN - 0968-0896
IS - 8
ER -
