Isolation and characterization of novel cytotoxic saponins from Archidendron ellipticum

John A. Beutler, Yoel Kashman, Lewis K. Pannell, John H. Cardellina, Mark R.A. Alexander, Michael S. Balaschak, Tanya R. Prather, Robert H. Shoemaker, Michael R. Boyd

Research output: Contribution to journalArticlepeer-review

Abstract

A series of new ester saponins, elliptosides A-J, has been isolated from the tropical plant Archidendron ellipticum (Leguminosae). These saponins were particularly cytotoxic to certain renal and melanoma cancer cell lines in the NCI's 60-cell line human tumor screen. The structures of elliptosides A, E, and F were elucidated by spectroscopic and chemical means. Elliptoside A showed in vivo antitumor activity against the LOX melanoma cell line.

Original languageEnglish
Pages (from-to)1509-1517
Number of pages9
JournalBioorganic and Medicinal Chemistry
Volume5
Issue number8
DOIs
StatePublished - Aug 1997

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