TY - JOUR
T1 - Isolated Glucosuria in Adolescence and Early-Onset Diabetes
T2 - A Nationwide Cohort Study of 1.6 Million Adolescents
AU - Vinograd, Adi
AU - Lerman, Tsahi T.
AU - Pinhas-Hamiel, Orit
AU - Bardugo, Aya
AU - Bendor, Cole D.
AU - Derazne, Estela
AU - Coresh, Josef
AU - Vinograd, Ofir
AU - Lutski, Miri
AU - Zucker, Inbar
AU - Bromberg, Michal
AU - Fishman, Tamar
AU - Chodick, Gabriel
AU - Gerstein, Hertzel C.
AU - Cukierman-Yaffe, Tali
AU - Vivante, Asaf
AU - Leiba, Adi
AU - Afek, Arnon
AU - Tirosh, Amir
AU - Fishman, Boris
AU - Twig, Gilad
N1 - Publisher Copyright:
© 2025 by the American Diabetes Association.
PY - 2025/5/1
Y1 - 2025/5/1
N2 - OBJECTIVE We assess diabetes risk in adulthood among adolescents with isolated glucosuria. RESEARCH DESIGN AND METHODS Included were adolescents (16–19 years) examined before military service between 1993 and 2015. Data were linked with the Israeli National Diabetes Registry. Glucosuria was confirmed following normal renal function and glucose tolerance tests. Cox models were applied. RESULTS The study included 1,611,467 adolescents, of whom 755 (0.05%) had glucosuria. The latter group had a higher proportion of males (75% vs. 57%) and a lower proportion of BMI $ 85th percentile (10.4% vs. 16.3%) compared with nonglucosuric (all P < 0.001). During follow-up, 10,328 diabetes cases were recorded with an incidence rate of 87.5 and 43.3 per 100,000 person-years for those with versus without glucosuria, respectively. Individuals with glucosuria had an adjusted hazard ratio of 2.17 (95% CI, 1.17–4.04) for diabetes. CONCLUSIONS Glucosuria in adolescents is associated with an increased risk of early-onset diabetes.
AB - OBJECTIVE We assess diabetes risk in adulthood among adolescents with isolated glucosuria. RESEARCH DESIGN AND METHODS Included were adolescents (16–19 years) examined before military service between 1993 and 2015. Data were linked with the Israeli National Diabetes Registry. Glucosuria was confirmed following normal renal function and glucose tolerance tests. Cox models were applied. RESULTS The study included 1,611,467 adolescents, of whom 755 (0.05%) had glucosuria. The latter group had a higher proportion of males (75% vs. 57%) and a lower proportion of BMI $ 85th percentile (10.4% vs. 16.3%) compared with nonglucosuric (all P < 0.001). During follow-up, 10,328 diabetes cases were recorded with an incidence rate of 87.5 and 43.3 per 100,000 person-years for those with versus without glucosuria, respectively. Individuals with glucosuria had an adjusted hazard ratio of 2.17 (95% CI, 1.17–4.04) for diabetes. CONCLUSIONS Glucosuria in adolescents is associated with an increased risk of early-onset diabetes.
UR - http://www.scopus.com/inward/record.url?scp=105004234191&partnerID=8YFLogxK
U2 - 10.2337/dc24-2402
DO - 10.2337/dc24-2402
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C2 - 40009774
AN - SCOPUS:105004234191
SN - 0149-5992
VL - 48
SP - 763
EP - 767
JO - Diabetes Care
JF - Diabetes Care
IS - 5
ER -
