Isolated fetal ascites caused by Wolman disease

A. Ben-Haroush*, Y. Yogev, O. Levit, M. Hod, B. Kaplan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Wolman disease is a rare autosomal-recessive disorder caused by reduced levels of lysosomal acid lipase. It occurs in infancy and is fatal in most cases before the age of 1 year. Affected infants show signs of lipid storage in most tissues, including hepatosplenomegaly, abdominal distension, vomiting, steatorrhea, failure to thrive, and adrenal calcifications. We present a case of isolated fetal ascites diagnosed at 32 weeks of gestation, with negative work-up for immune and non-immune hydrops fetalis and congenital infections and malformations. After delivery, the diagnosis of Wolman disease was established. Although rare, storage diseases such as Wolman disease should be considered in cases of isolated fetal ascites.

Original languageEnglish
Pages (from-to)297-298
Number of pages2
JournalUltrasound in Obstetrics and Gynecology
Issue number3
StatePublished - 1 Mar 2003


  • Ascites
  • Lipid metabolism
  • Storage disease
  • Ultrasound
  • Wolman disease


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