TY - JOUR
T1 - Ischemic preconditioning of the heart
AU - Eisen, Alon
AU - Schwammenthal, Ehud
AU - Adler, Yehuda
PY - 2008/2
Y1 - 2008/2
N2 - The phenomenon of ischemic preconditioning" has been well known for nearly two decades. In this phenomenon, a brief period of ischemia prior to a more prolonged one improves myocardial function and reduces infarction. This phenomenon is described in animals and, in recent years, also in human hearts, in vitro and in vivo. Two types of ischemic preconditioning are known: the classic or early preconditioning and the delayed or late preconditioning. The mechanism of late preconditioning is well described and is different from its early phase. Fully understanding the mechanism of this amazing phenomenon promises to be a novel discovery as for developing preconditioning mimetic agents and, thereby, using preconditioning as a therapeutic tool or as a preventive factor in cardiovascular diseases.
AB - The phenomenon of ischemic preconditioning" has been well known for nearly two decades. In this phenomenon, a brief period of ischemia prior to a more prolonged one improves myocardial function and reduces infarction. This phenomenon is described in animals and, in recent years, also in human hearts, in vitro and in vivo. Two types of ischemic preconditioning are known: the classic or early preconditioning and the delayed or late preconditioning. The mechanism of late preconditioning is well described and is different from its early phase. Fully understanding the mechanism of this amazing phenomenon promises to be a novel discovery as for developing preconditioning mimetic agents and, thereby, using preconditioning as a therapeutic tool or as a preventive factor in cardiovascular diseases.
KW - Ischemia
KW - Ischemic preconditioning
KW - Myocardial infarction
KW - Myocardial protection
KW - Therapeutic tool
UR - http://www.scopus.com/inward/record.url?scp=43549099811&partnerID=8YFLogxK
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C2 - 18357677
AN - SCOPUS:43549099811
SN - 0017-7768
VL - 147
SP - 163
EP - 168
JO - Harefuah
JF - Harefuah
IS - 2
ER -