Ischemic LTP: NMDA-dependency and dorso/ventral distribution within the hippocampus

Nicola Maggio, Efrat Shavit Stein, Menahem Segal

Research output: Contribution to journalArticlepeer-review

Abstract

A transient ischemic episode causes a reduction in evoked EPSPs in hippocampal slices, followed by an NMDA dependent LTP. We explored the relations between ischemic LTP (iLTP) and the more conventional tetanic LTP (tLTP) in CA1 region of slices along the dorsal/ventral axis of the hippocampus. Dorsal hippocampal (DH) slices produced a much larger iLTP than their ventral hippocampal (VH) counterparts. In both regions, iLTP and tLTP shared the same NMDA mediated potentiation, such that one LTP saturated the ability of the other treatment to generate LTP. The smaller LTP in VH was correlated with a lower NMDA-mediated EPSP, and a parallel lower density of NMDA receptors. Calcium permeable AMPA receptors did not contribute to the DH/VH disparity. We conclude that a differential distribution of NMDA receptor subunits along the septotemporal axis of the hippocampus controls the diverse ability to evoke iLTP and tLTP in the two regions and may underlie their characteristic behavioral outputs as well as their differential sensitivity to ischemia.

Original languageEnglish
Pages (from-to)1465-1471
Number of pages7
JournalHippocampus
Volume25
Issue number11
DOIs
StatePublished - Nov 2015
Externally publishedYes

Keywords

  • Dorsal hippocampus
  • Ischemic LTP
  • LTP
  • NMDA receptors

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