Is Ultra Hypofractionated Radiation Therapy a Safe and Effective Treatment for Invasive Bladder Cancer in the Elderly? A Retrospective Single Institution Review

Noam Symon, Jacoubo Mattout, Ron Lewin, Liat Hammer, Menachem Laufer, Raanan Berger, Raya Leibowitz, Zohar Dotan, Maoz Ben-Ayun, Lev Tsvang, Ilana Weiss, Zvi Symon*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Purpose: The aim was to determine the efficacy, safety, and tolerability of weekly ultra hypofractionated radiation therapy for older unfit patients with invasive bladder cancer. Methods: We retrospectively analyzed a cohort of patients with muscle invasive bladder cancer deemed unfit for chemoradiation therapy and thus treated with 6 weekly doses of 6 Gy using intensity modulated radiotherapy. Charlson comorbidity was calculated retrospectively. Cystoscopy and computed tomography were used to evaluate local control and toxicity using the common terminology criteria. Survival outcomes were estimated using the Kaplan-Meier method. Results: Twenty-two patients with a median age of 84 (range: 70 to 96) years were included. The median comorbidity index was 6±1.5 SD. Nineteen (90%) patients received the full 36 Gy dose. Median follow-up was 10±7 months (range: 6 to 27 mo). Local control in the bladder was achieved in 16 of 19 evaluable patients (84%). One-year overall survival was 62.5%, 1 patient had a retroperitoneal nodal recurrence and 3 patients developed distant metastasis. Grade 3 genitourinary and gastrointestinal toxicity was observed in 4 (18%) and 1 (4.5%) patients, respectively. Conclusion: Weekly ultra hypofractionated intensity modulated radiotherapy with image guidance and bladder training is an effective, safe, and well-tolerated regimen for older patients with invasive bladder cancer unfit for radical treatment.

Original languageEnglish
Pages (from-to)369-373
Number of pages5
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Volume44
Issue number7
DOIs
StatePublished - Jul 2021

Keywords

  • frail older patients
  • hypofractionated radiation therapy
  • invasive bladder cancer

Fingerprint

Dive into the research topics of 'Is Ultra Hypofractionated Radiation Therapy a Safe and Effective Treatment for Invasive Bladder Cancer in the Elderly? A Retrospective Single Institution Review'. Together they form a unique fingerprint.

Cite this