Is there any sense in antisense editing?

Yossef Neeman, Dvir Dahary, Erez Y. Levanon, Rotem Sorek, Eli Eisenberg

Research output: Contribution to journalShort surveypeer-review

Abstract

Several recent studies have hypothesized that sense-antisense RNA-transcript pairs create dsRNA duplexes that undergo extensive A-to-I RNA editing. We studied human and mouse genomic antisense regions and found that the editing level in these areas is negligible. This observation questions the scope of sense-antisense duplexes formation in-vivo, which is the basis for several proposed regulatory mechanisms.

Original languageEnglish
Pages (from-to)544-547
Number of pages4
JournalTrends in Genetics
Volume21
Issue number10
DOIs
StatePublished - Oct 2005

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