Is there a place for screening flexible sigmoidoscopy?

Doron Boltin, Yaron Niv*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Flexible sigmoidoscopy is a valid screening tool for the early detection of colorectal cancer (CRC). Recently published long-term data from UKFSST, a randomized controlled trial, demonstrate a 33% reduction in colorectal cancer incidence and a 43% decrease in colorectal cancer mortality, with once-in-a-lifetime screening. On the other hand, data from the NORCCAP trial with a similar protocol show no reduction in CRC incidence and only nonsignificant decrease in CRC mortality at 7 years. At best, flexible sigmoidoscopy can detect only 70% of cancers and polyps as it does not detect the 40% of proximal neoplasms which are not associated with a distal lesion. The advantage of flexible sigmoidoscopy over other screening modalities lies in its safety profile, patient tolerance, and overall acceptance. Its technical simplicity, short duration, and cost-effectiveness advance its applicability to mass screening programs.

Original languageEnglish
Pages (from-to)16-21
Number of pages6
JournalCurrent Colorectal Cancer Reports
Issue number1
StatePublished - Mar 2012


  • Colorectal cancer
  • Flexible sigmoidoscopy
  • Prevention and early detection
  • Screening


Dive into the research topics of 'Is there a place for screening flexible sigmoidoscopy?'. Together they form a unique fingerprint.

Cite this