Is there a difference in testosterone levels and its regulators in men carrying BRCA mutations?

Hanan Goldberg, Liat Shavit Grievink, Roy Mano, Yaara Ber, Rachely Ozalbo, Sivan Tuval, Jack Baniel, David Margel

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Male BRCA mutation carriers are at risk for an early onset aggressive prostate cancer. No data exist on the association of testosterone levels among these patients. We aimed to analyze testosterone and associated hormonal levels among male BRCA carriers and non-carriers. Patients and methods: Overall 87 male carriers and 43 non-carriers aged 40- 70 were prospectively enrolled. Clinical data were collected and all patients were tested for total testosterone (TT), prostate specific antigen (PSA), follicle stimulating hormone (FSH), luteinizing hormone (LH), free androgen index (FAI), sex hormone binding globulin (SHBG) and prolactin. Multivariate linear regression analysis was performed to predict TT levels. Results: The median age, mean BMI, comorbidities, PSA, FSH, LH and SHBG levels in both groups were similar. However, mean TT and FAI were higher in the carriers (16.7 nmol/l vs 13.5 nmol/l, p=0.03 and 39.5 vs 34.8, p=0.05, respectively), while prolactin was significantly lower. Multivariate analysis demonstrated that while BMI was inversely correlated to TT levels in both groups, LH was a predictor only in noncarriers. Conclusions: Carriers have higher TT and FAI levels and lower prolactin levels; but LH does not predict their TT levels. Further research in a larger cohort of BRCA carriers with and without prostate cancer should be performed.

Original languageEnglish
Pages (from-to)103843-103850
Number of pages8
JournalOncotarget
Volume8
Issue number61
DOIs
StatePublished - 2017

Keywords

  • BRCA mutations
  • Free androgen index
  • Luteinizing hormone
  • Prostate cancer
  • Testosterone

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