Is magnesium depletion the reason for ototoxicity caused by aminoglycosides?

Eran Dolev, Arnon Tamir, George Leventon

Research output: Contribution to journalArticlepeer-review

Abstract

Aminoglycoside antibiotic drugs may cause ototoxicity and nephrotoxicity. Our hypothesis postulates that aminoglycosides cause ototoxicity by a mechanism of magnesium depletion in the hair cells of the cochlea. The same mechanism maybe responsible for nephrotoxicity caused by aminoglycosides.

Original languageEnglish
Pages (from-to)353-358
Number of pages6
JournalMedical Hypotheses
Volume10
Issue number4
DOIs
StatePublished - Apr 1983
Externally publishedYes

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