Is magnesium depletion the reason for ototoxicity caused by aminoglycosides?

Eran Dolev; Arnon Tamir; George Leventon

doi:10.1016/0306-9877(83)90002-6

Is magnesium depletion the reason for ototoxicity caused by aminoglycosides?

Eran Dolev^*, Arnon Tamir, George Leventon

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Aminoglycoside antibiotic drugs may cause ototoxicity and nephrotoxicity. Our hypothesis postulates that aminoglycosides cause ototoxicity by a mechanism of magnesium depletion in the hair cells of the cochlea. The same mechanism maybe responsible for nephrotoxicity caused by aminoglycosides.

Original language	English
Pages (from-to)	353-358
Number of pages	6
Journal	Medical Hypotheses
Volume	10
Issue number	4
DOIs	https://doi.org/10.1016/0306-9877(83)90002-6
State	Published - Apr 1983
Externally published	Yes

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10.1016/0306-9877(83)90002-6

Cite this

@article{eb788dbda1d848d5b3dd964b5adfaaee,

title = "Is magnesium depletion the reason for ototoxicity caused by aminoglycosides?",

abstract = "Aminoglycoside antibiotic drugs may cause ototoxicity and nephrotoxicity. Our hypothesis postulates that aminoglycosides cause ototoxicity by a mechanism of magnesium depletion in the hair cells of the cochlea. The same mechanism maybe responsible for nephrotoxicity caused by aminoglycosides.",

author = "Eran Dolev and Arnon Tamir and George Leventon",

year = "1983",

month = apr,

doi = "10.1016/0306-9877(83)90002-6",

language = "אנגלית",

volume = "10",

pages = "353--358",

journal = "Medical Hypotheses",

issn = "0306-9877",