Is Her-2/neu expressed in nonepithelial ovarian malignancies?

Joseph Menczer; Letizia Schreiber; Bernard Czernobilsky; Esther Berger; Abraham Golan; Tally Levy

doi:10.1016/j.ajog.2006.07.050

Is Her-2/neu expressed in nonepithelial ovarian malignancies?

Joseph Menczer^*, Letizia Schreiber, Bernard Czernobilsky, Esther Berger, Abraham Golan, Tally Levy

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Objective: The objective of this study was to assess the expression of Her-2/neu in nonepithelial ovarian malignancies. Study design: Formalin-fixed paraffin-embedded archival tissue blocks of 20 unselected nonepithelial ovarian malignancies (12 granulosa cell tumors and 8 germ cell tumors) diagnosed between 1993 and 2005 were immunohistochemically stained for Her-2/neu. Results: Immunohistochemical staining for Her-2/neu was not present in any of these nonepithelial malignancies examined. Conclusion: Our limited sample size does not allow a generalized conclusion concerning the lack of Her-2/neu expression in nonepithelial ovarian malignancies, but it adds information with regard to the expression of this oncogene in these rare neoplasms and seems to indicate that it is not a frequent occurrence.

Original language	English
Pages (from-to)	79.e1-79.e4
Journal	American Journal of Obstetrics and Gynecology
Volume	196
Issue number	1
DOIs	https://doi.org/10.1016/j.ajog.2006.07.050
State	Published - Jan 2007

Keywords

Her-2/neu
germ cell tumor
granulosa cell tumor

Access to Document

10.1016/j.ajog.2006.07.050

Cite this

@article{f2d9ee156fc64727a30371d779b59818,

title = "Is Her-2/neu expressed in nonepithelial ovarian malignancies?",

abstract = "Objective: The objective of this study was to assess the expression of Her-2/neu in nonepithelial ovarian malignancies. Study design: Formalin-fixed paraffin-embedded archival tissue blocks of 20 unselected nonepithelial ovarian malignancies (12 granulosa cell tumors and 8 germ cell tumors) diagnosed between 1993 and 2005 were immunohistochemically stained for Her-2/neu. Results: Immunohistochemical staining for Her-2/neu was not present in any of these nonepithelial malignancies examined. Conclusion: Our limited sample size does not allow a generalized conclusion concerning the lack of Her-2/neu expression in nonepithelial ovarian malignancies, but it adds information with regard to the expression of this oncogene in these rare neoplasms and seems to indicate that it is not a frequent occurrence.",

keywords = "Her-2/neu, germ cell tumor, granulosa cell tumor",

author = "Joseph Menczer and Letizia Schreiber and Bernard Czernobilsky and Esther Berger and Abraham Golan and Tally Levy",

year = "2007",

month = jan,

doi = "10.1016/j.ajog.2006.07.050",

language = "אנגלית",

volume = "196",

pages = "79.e1--79.e4",

journal = "American Journal of Obstetrics and Gynecology",

issn = "0002-9378",