Is dementia preventable? Focus on Alzheimers disease

Yoram Barak*, Dov Aizenberg

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


The prevention of dementia, and particularly of Alzheimers disease, is a major challenge for researchers and clinicians. In this article, the mixture of evidence, observations and hypotheses in the current literature is categorized into four avenues for possible preventive interventions, as suggested by the NIH State-of-the-Science Conference. The main categories are: antihypertensive medications; nutrition; cognitive engagement; and physical activity. There is, as yet, no conclusive evidence, but each category may hold promise for the prevention of dementia. The robust findings are as follows: cognitive engagement and regular physical activity may reduce the risk of Alzheimers disease; the Mediterranean diet and consumption of omega-3 fatty acids deserves further elucidation; and the meticulous management of risk factors, and especially hypertension, is the infrastructure of Alzheimers disease prevention.

Original languageEnglish
Pages (from-to)1689-1698
Number of pages10
JournalExpert Review of Neurotherapeutics
Issue number11
StatePublished - Nov 2010


  • Alzheimers disease
  • cognitive engagement
  • dementia
  • hypertensive medications
  • nutrition
  • omega-3 fatty acids
  • physical activity
  • prevention


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