Is abundant A-to-I RNA editing primate-specific?

Eli Eisenberg, Sergey Nemzer, Yaron Kinar, Rotem Sorek, Gideon Rechavi, Erez Y. Levanon

Research output: Contribution to journalShort surveypeer-review

Abstract

A-to-I RNA editing is common in all eukaryotes, and is associated with various neurological functions. Recently, A-to-I editing was found to occur frequently in the human transcriptome. In this article, we show that the frequency of A-to-I editing in humans is at least an order of magnitude higher than in the mouse, rat, chicken or fly genomes. The extraordinary frequency of RNA editing in human is explained by the dominance of the primate-specific Alu element in the human transcriptome, which increases the number of double-stranded RNA substrates.

Original languageEnglish
Pages (from-to)77-81
Number of pages5
JournalTrends in Genetics
Volume21
Issue number2
DOIs
StatePublished - Feb 2005

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