Irreversible electroporation: Evolution of a laboratory technique in interventional oncology

Amy R. Deipolyi, Alexander Golberg, Martin L. Yarmush, Ronald S. Arellano, Rahmi Oklu*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Electroporation involves applying electric field pulses to cells, leading to the alteration or destruction of cell membranes. Irreversible electroporation (IRE) creates permanent defects in cell membranes and induces cell death. By directly targeting IRE to tumors, percutaneous nonthermal ablation is possible. The history of IRE, evolution of concepts, theory, biological applications, and clinical data regarding its safety and efficacy are discussed.

Original languageEnglish
Pages (from-to)147-154
Number of pages8
JournalDiagnostic and Interventional Radiology
Volume20
Issue number2
DOIs
StatePublished - 2014
Externally publishedYes

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