Irradiation of Fresh Whole Blood for Prevention of Transfusion‐Associated Graft‐versus‐Host Disease Does Not Impair Platelet Function and Clinical Hemostasis after Open Heart Surgery

J. Lavee, A. Shinfeld, N. Savion, M. Thaler, R. Mohr, D. A. Goor

Research output: Contribution to journalArticlepeer-review

Abstract

Since our previous studies suggested that the transfusion of 1 unit fresh whole blood (FWB) after cardiopulmonary bypass (CPB) using a bubble oxygenator may provide hemostatic benefit equivalent to 8–10 units of platelet concentrates, we have routinely used FWB at the termination of CPB. Two patients who received FWB and developed transfusion‐associated graft‐versus‐host disease (TA‐GVHD) prompted us to investigate the effect of irradiation of FWB on platelet and clinical hemostasis. Twenty‐four patients were randomized to receive either 1 unit FWB (12 patients), or 1 unit irradiated FWB (IrFWB, 1,500 cGy, 12 patients) after CPB. Platelet aggregation on extracellular matrix, studied by a scanning electron microscope and graded from 1 to 4 (from poor to excellent aggregation), was similar in both groups preoperatively [3.3±0.9 (FWB) and 3.5±0.5 (Ir FWB)], and at the end of CPB [1.8±1.2 (FWB) and 1.9±0.9 (IrFWB)]. Platelet aggregation was similar after transfusion of FWB (3.0±1.0) and after IrFWB (3.2±0.8), as was the increase in platelet count. Twenty‐four hours total postoperative bleeding was similar (560±420 and 523±236 ml for FWB and IrFWB, respectively). We conclude that irradiation of FWB for prevention of TA‐GVHD does not impair platelet aggregating capacity, and can be used when blood is donated by the patient's next of kin.

Original languageEnglish
Pages (from-to)104-109
Number of pages6
JournalVox Sanguinis
Volume69
Issue number2
DOIs
StatePublished - Aug 1995

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