Iron polymaltose versus ferrous gluconate in the prevention of iron deficiency anemia of infancy

Lutfi Jaber, Shmuel Rigler, Ahmad Taya, Fadel Tebi, Mohamad Baloum, Isaac Yaniv, Mohamad Haj Yehia, Hanna Tamary

Research output: Contribution to journalArticlepeer-review


We prospectively compared the efficacy and safety of iron deficiency anemia prophylaxis with iron gluconate (IG) or iron polymaltose complex (IPC) in healthy infants attending a community pediatric center. Participants were randomly assigned to receive one of the test drugs from age 4 to 6 months to age 12 months. Parents/guardians were given extensive information on iron-rich diets and anemia prevention. Main outcome measures were blood levels of hemoglobin, hematocrit, mean corpuscular volume, red blood cell distribution width, and serum iron, ferritin, and transferrin, in addition to adverse effects. One hundred five children completed the study: 53 in the IG group and 52 in the IPC group Mean hemoglobin levels at study end were significantly higher in the IG group (12.04±0.09 g/dL vs. 11.68±0.11, P<0.014). A hemoglobin level <11? g/dL was detected in 3 infants of the IG group, and in 10 infants of the IPC group (P<0.04). Adverse effects (spitting, vomiting, diarrhea, constipation, discolored teeth) were significantly more common in the IG group (47% vs. 25%, P>0.025). In conclusion, both oral IG and IPC prevent iron deficiency anemia in infants. Iron gluconate seems to be more effective but less tolerable.

Original languageEnglish
Pages (from-to)585-588
Number of pages4
JournalJournal of Pediatric Hematology/Oncology
Issue number8
StatePublished - Nov 2010


  • Iron gluconate
  • anemia
  • iron deficiency anemia
  • iron polymaltose complex


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