Iron deficiency anemia in patients without gastrointestinal symptoms - A prospective study

Eva Niv, Avishay Elis, Rivka Zissin, Timna Naftali, Ben Novis, Michael Lishner

Research output: Contribution to journalArticlepeer-review

Abstract

Background and objectives. Chronic gastrointestinal (GI) bleeding is the leading cause of iron deficiency anaemia (IDA) in men older than 50 years and post-menopausal women. There is a scarcity of data regarding IDA patients without GI symptoms or signs. We conducted a prospective study to determine the prevalence and the locations of the GI tract lesions in patients with asymptomatic IDA. Methods. Forty-eight patients with asymptomatic IDA (25 men older than 50 years and 23 post-menopausal women) underwent colonoscopy, gastroscopy and abdominal computed tomography (CT) with contrast agent. Results. An anaemia-causing lesion was found in 14 (29%) and 16 (33%) patients in the upper and the lower GI tract, respectively. The prevalence of dual lesions (in both the upper and lower GI tract) was low (6%). In 14 (29%) patients, a malignancy, predominantly right-sided colon carcinoma, was responsible for the IDA. Only one patient had a lesion in the small bowel. In 14 (29%) patients, the work-up was negative. Conclusion. Our prospective study demonstrates a high rate of malignancy, predominantly right-sided colon carcinoma, in men older than 50 years and post-menopausal women with asymptomatic IDA. This finding obligates a complete and rigorous GI tract examination in this group of patients, especially of the right colon.

Original languageEnglish
Pages (from-to)58-61
Number of pages4
JournalFamily Practice
Volume22
Issue number1
DOIs
StatePublished - Feb 2005

Keywords

  • Asymptomatic
  • Iron deficiency anaemia

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