IR-biosensor: Flat silver halide fiber for bio-medical sensing?

U. Bindig, M. Meinke, I. Gersonde, O. Spector, I. Vasserman, A. Katzir, G. Müller

Research output: Contribution to journalConference articlepeer-review

Abstract

Cylindrical optical fibers, made of various materials, have been used for decades for chemical and biological sensing. Optical fibers transparent in the mid-infrared (IR) enable absorption measurements in remote locations. New techniques will enable the use of IR fibers for measurements in ATR-mode. If the fiber is in contact with a sample that has characteristic absorption lines, the total transmission of the fiber and sample of these lines will decrease. In this way the absorption of a sample can be determined using a non-destructive method. This work proves that flattened silver halide fibers could be useful as sensing elements in analytical systems. First measurements using flattened IR-fibers have been carried out on biological targets. The experimental set-up used was made up of an FTIR-spectrometer, fiber optic cables and an external detector. A segment of 1.9 cm at the center of the fiber was flattened to approximately 100-150 μm. Transmission spectra of flattened fibers have been compared to those of the cylindrical fibers. IR-spectra were recorded for biochemical compounds such as glucose, bovine serum albumin (BSA), gelatin and bio-fluids, and native tissue was compared to coagulated tissue. Spectral differences were obtained indicating a possible use for the study of thermal damage in tissues.

Original languageEnglish
Pages (from-to)37-46
Number of pages10
JournalSensors and Actuators, B: Chemical
Volume74
Issue number1-3
DOIs
StatePublished - 15 Apr 2001
Event5th European Conference on Optical Chemical Sensors and Biosensors - Lyon, France
Duration: 16 Apr 200019 Apr 2000

Keywords

  • Coagulation
  • Fiber evanescent wave spectroscopy (FEWS)
  • Flattened IR-fiber
  • Tissue

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