Abstract
To study the influence of sympathetic innervation on the amount of threshold shift (TS) induced by sound overstimulation, iontophoresis with phentolamine, a known adrenergic alpha-blocker, was performed on awake guinea pigs. The sound exposure following this induced a significantly lesser degree of TS when compared with the control group. These findings indicate that iontophoresis may be of great help in transporting specific ionized chemical compounds through the intact cochlear walls in a completely non-invasive manner for studying cochlear physiology.
| Original language | English |
|---|---|
| Pages (from-to) | 345-347 |
| Number of pages | 3 |
| Journal | European Archives of Oto-Rhino-Laryngology |
| Volume | 247 |
| Issue number | 6 |
| DOIs | |
| State | Published - Sep 1990 |
Keywords
- Acoustic overstimulation
- Phentolamine
- lontophoresis