Involvement of the neuropeptide corticotropin-releasing hormone in an animal model of Shigella-related seizures

Yael Yuhas, Abraham Weizman, George P. Chrousos, Hilla Ovadia, Shai Ashkenazi

Research output: Contribution to journalArticlepeer-review

Abstract

Convulsions are common complications of shigellosis in children. Corticotropin-releasing hormone (CRH), a stress neurohormone, has been implicated in the susceptibility of young children to seizures. We investigated the role of CRH in Shigella-related seizures. Pretreatment with Shigella dysenteriae sonicate enhanced mice response to pentylenetetrazole (PTZ)-induced seizures. Preinjection of antalarmin, a CRH-receptor 1 antagonist, decreased both the mean convulsion score (MCS: 1.6 vs. 1.1, p<0.05) and the percent of mice having seizures (48% vs. 28%, p=0.03). This indicates that CRH plays a role in the increased susceptibility to seizures following exposure to S. dysenteriae.

Original languageEnglish
Pages (from-to)36-39
Number of pages4
JournalJournal of Neuroimmunology
Volume153
Issue number1-2
DOIs
StatePublished - Aug 2004

Keywords

  • Children
  • Cortricotropin-releasing hormone (CRH)
  • Seizures
  • Shigella

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