Involvement of prostaglandins in an animal model of Shigella-related seizures

Yael Yuhas; Avraham Weizman; Alexey Vanichkin; Shai Ashkenazi

doi:10.1016/j.jneuroim.2005.06.029

Involvement of prostaglandins in an animal model of Shigella-related seizures

Yael Yuhas^*, Avraham Weizman, Alexey Vanichkin, Shai Ashkenazi

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

We investigated whether prostaglandins (PGs), proinflammatory mediators implicated in excitatory activity, are involved in Shigella-related seizures. Pretreatment with S. dysenteriae sonicate (2LD₅₀) enhanced mice response to pentylenetetrazole-induced seizures, without increase of brain concentrations of PGE₂, PGD₂ or PGF_2α. Preinjection of NS-398, an inhibitor of cyclooxygenase-2, before treatment with Shigella sonicate, had no effect on seizures. The anticonvulsive PGD₂ increased after injection of 8 LD₅₀ of Shigella sonicate, which did not enhance seizures (32 pg/mg vs 26 pg/ml, p = 0.0063). The findings indicate that PGs are not involved in the enhanced seizure response after exposure to Shigella. However, induction of PGD₂ may play an inhibitory role.

Original language	English
Pages (from-to)	34-39
Number of pages	6
Journal	Journal of Neuroimmunology
Volume	168
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2005.06.029
State	Published - Nov 2005

Keywords

Animal model
Prostaglandins
Seizures
Shigella

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10.1016/j.jneuroim.2005.06.029

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title = "Involvement of prostaglandins in an animal model of Shigella-related seizures",

abstract = "We investigated whether prostaglandins (PGs), proinflammatory mediators implicated in excitatory activity, are involved in Shigella-related seizures. Pretreatment with S. dysenteriae sonicate (2LD50) enhanced mice response to pentylenetetrazole-induced seizures, without increase of brain concentrations of PGE2, PGD2 or PGF2α. Preinjection of NS-398, an inhibitor of cyclooxygenase-2, before treatment with Shigella sonicate, had no effect on seizures. The anticonvulsive PGD2 increased after injection of 8 LD50 of Shigella sonicate, which did not enhance seizures (32 pg/mg vs 26 pg/ml, p = 0.0063). The findings indicate that PGs are not involved in the enhanced seizure response after exposure to Shigella. However, induction of PGD2 may play an inhibitory role.",

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AU - Yuhas, Yael

AU - Weizman, Avraham

AU - Vanichkin, Alexey

AU - Ashkenazi, Shai

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N2 - We investigated whether prostaglandins (PGs), proinflammatory mediators implicated in excitatory activity, are involved in Shigella-related seizures. Pretreatment with S. dysenteriae sonicate (2LD50) enhanced mice response to pentylenetetrazole-induced seizures, without increase of brain concentrations of PGE2, PGD2 or PGF2α. Preinjection of NS-398, an inhibitor of cyclooxygenase-2, before treatment with Shigella sonicate, had no effect on seizures. The anticonvulsive PGD2 increased after injection of 8 LD50 of Shigella sonicate, which did not enhance seizures (32 pg/mg vs 26 pg/ml, p = 0.0063). The findings indicate that PGs are not involved in the enhanced seizure response after exposure to Shigella. However, induction of PGD2 may play an inhibitory role.

AB - We investigated whether prostaglandins (PGs), proinflammatory mediators implicated in excitatory activity, are involved in Shigella-related seizures. Pretreatment with S. dysenteriae sonicate (2LD50) enhanced mice response to pentylenetetrazole-induced seizures, without increase of brain concentrations of PGE2, PGD2 or PGF2α. Preinjection of NS-398, an inhibitor of cyclooxygenase-2, before treatment with Shigella sonicate, had no effect on seizures. The anticonvulsive PGD2 increased after injection of 8 LD50 of Shigella sonicate, which did not enhance seizures (32 pg/mg vs 26 pg/ml, p = 0.0063). The findings indicate that PGs are not involved in the enhanced seizure response after exposure to Shigella. However, induction of PGD2 may play an inhibitory role.

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KW - Seizures

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Involvement of prostaglandins in an animal model of Shigella-related seizures

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