Investigations on Carnitine Derivatives in Human Seminal Fluid

J. Frankel*, Lawrence Lewin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Free L‐carnitine and its derivatives, present in human seminal fluid, were fractionated on Dowex 50WX8 (H +) cation exchange columns by sequential elution with HCl (1 M, 2.5 M and 4 M). Free L‐carnitine eluted with 1 M HCl, whereas other carnitine‐containing materials eluted with 2.5 M and 4 M HCl. Chromatography of semen extracts on Whatman No 1 paper likewise resolved three classes of materials which satisfied the carnitine requirement of Torulopsis bovina ATCC 26014. In addition to water soluble alkali‐hydrolyzable materials with the properties of short chain acylcarnitines, there was another carnitine derivative, resistant to hydrolysis, which eluted from Dowex 50 W columns with 4 M HCl. It was concluded the human semen contains free carnitine. short chain acylcarnitines and an unidentified highly polar carnitine derivative.

Original languageEnglish
Pages (from-to)299-307
Number of pages9
JournalInternational Journal of Andrology
Issue number1-6
StatePublished - Dec 1979


  • Carnitine
  • acylcarnitines
  • semen
  • seminal fluid


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