Baclofen was administered intrathecally to four patients suffering from severe low back pain accompanied by contracted paraspinal muscles and secondary lumbar scoliosis. Neurological signs were absent in all the patients. The intrathecal injection of baclofen 0.25 mg resulted in the disappearance of pain and tendon stretch reflexes within 1 hour. The pain reappeared after 3-6 hours and the tendon reflexes after 26-32 hours. The H and T electrical reflexes also disappeared for 28-32 hours. Muscle strength and sensation were preserved. The EMG and motor nerve conduction remained normal. A state of hypotonia caused unstable ambulation and transient urinary retention.
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|Published - 1988