TY - CHAP
T1 - Investigating the Connection Between Tumor-Treating Fields Distribution in the Brain and Glioblastoma Patient Outcomes. A Simulation-Based Study Utilizing a Novel Model Creation Technique
AU - Urman, Noa
AU - Levy, Shay
AU - Frenkel, Avital
AU - Manzur, Doron
AU - Hershkovich, Hadas Sara
AU - Naveh, Ariel
AU - Yesharim, Ofir
AU - Wenger, Cornelia
AU - Lavy-Shahaf, Gitit
AU - Kirson, Eilon
AU - Bomzon, Ze’ev
N1 - Publisher Copyright:
© The Editor(s) (if applicable) and The Author(s) 2019.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Here we describe preliminary results of a simulation-based study investigating the connection between tumor-treating fields (TTFields) distribution in the brain and glioblastoma patient outcomes. In order to perform this study, we developed a semiautomatic method for creating realistic head models from glioblastoma patient MRI using a deformable template and atlas-based registration. This method, which is described in detail in this chapter, is robust and fast, making it suitable for rapid creation of multiple realistic head models. Using this method, we created 119 head models of newly diagnosed glioblastoma patients that were treated with tumor-treating fields. Finite element simulations were used to simulate delivery of TTFields to these patients, and the connection between field intensity distribution at the tumor bed and patient outcome was analyzed. The result of this analysis support the hypothesis that increasing field intensity at the tumor bed improves patient outcome.
AB - Here we describe preliminary results of a simulation-based study investigating the connection between tumor-treating fields (TTFields) distribution in the brain and glioblastoma patient outcomes. In order to perform this study, we developed a semiautomatic method for creating realistic head models from glioblastoma patient MRI using a deformable template and atlas-based registration. This method, which is described in detail in this chapter, is robust and fast, making it suitable for rapid creation of multiple realistic head models. Using this method, we created 119 head models of newly diagnosed glioblastoma patients that were treated with tumor-treating fields. Finite element simulations were used to simulate delivery of TTFields to these patients, and the connection between field intensity distribution at the tumor bed and patient outcome was analyzed. The result of this analysis support the hypothesis that increasing field intensity at the tumor bed improves patient outcome.
KW - Quasi-electrostatic simulations
KW - Segmentation
KW - TTFields realistic head models
KW - Tumor-treating fields
UR - http://www.scopus.com/inward/record.url?scp=85111152887&partnerID=8YFLogxK
U2 - 10.1007/978-3-030-21293-3_7
DO - 10.1007/978-3-030-21293-3_7
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AN - SCOPUS:85111152887
SN - 9783030212926
SP - 139
EP - 154
BT - Brain and Human Body Modeling
PB - Springer International Publishing
ER -