Invasive Fungal Pneumonia in Immunocompromised Patients

Myrna C.B. Godoy*, Hanna R. Ferreira Dalla Pria, Mylene T. Truong, Girish S. Shroff, Edith M. Marom

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Fungal pneumonia is the most frequent presentation of invasive fungal infections (IFIs) in patients with hematologic malignancies (HM) and hematopoietic stem cell transplantation (HSCT) recipients. The most common causes include Aspergillus, Mucor, Fusarium, and Candida species. The high incidence and high morbidity and mortality rate of fungal pneumonias in HM/HSCT populations arise from severe immune dysfunction that may be caused by both the underlying disease and/or its treatment. CT is routinely used when pulmonary complications are suspected after HSCT. Appropriate image interpretation of the posttransplant patient requires a combination of pattern recognition and knowledge of the clinical setting. In this article, we provide an overview of the clinical manifestations and CT imaging features of the most common invasive fungal pneumonias (IFPs) seen in severely immunosuppressed hosts.

Original languageEnglish
Pages (from-to)497-506
Number of pages10
JournalRadiologic Clinics of North America
Volume60
Issue number3
DOIs
StatePublished - May 2022

Keywords

  • Adverse effects
  • Computed X-ray tomography
  • Fungal pneumonia
  • Hematopoietic stem cell transplantation
  • Pulmonary aspergillosis
  • Pulmonary candidiasis
  • Pulmonary mucormycosis

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