Invariant chain induces B cell maturation in a process that is independent of its chaperonic activity

Didi Matza, Frida Lantner, Yoel Bogoch, Liat Flaishon, Rami Hershkoviz, Idit Shachar

Research output: Contribution to journalArticlepeer-review

Abstract

Early stages of B cell development take place in the bone marrow, resulting in formation of immature B cells, which migrate to the spleen for their final differentiation into mature cells. This final maturation step is essential for B cells to become responsive to antigens and to participate in the immune response. Previously, we showed that the MHC class II chaperone, invariant chain (Ii), controls the differentiation of B cells from the immature to the mature stage. In this study, by generating transgenic mice expressing truncated Ii lacking its luminal domain, we could dissect the chaperonin activity of Ii from its role in B cell maturation. We demonstrate in vivo that Ii N-terminal domain is directly involved in the maturation of B cells and is sufficient to promote B cell differentiation.

Original languageEnglish
Pages (from-to)3018-3023
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume99
Issue number5
DOIs
StatePublished - 5 Mar 2002
Externally publishedYes

Keywords

  • Antigen presentation
  • Immature B cell
  • Mature B cell
  • N-terminal domain
  • Transgenic mice

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