TY - JOUR
T1 - Introduction to Protein Ensembles and Allostery
AU - Nussinov, Ruth
N1 - Funding Information:
This project has been funded in whole or in part with Federal funds from the Frederick National Laboratory for Cancer Research, National Institutes of Health, under contract HHSN261200800001E.
PY - 2016/6/8
Y1 - 2016/6/8
N2 - This thematic issue of Chemical Reviews focuses on allostery and protein Ensemble, including the populations of conformational states which constitute their physical foundation. The awareness of the immense significance of allostery in practically all biological processes, as assessed from the sheer statistics of studies centering on the concept, on elucidation of the mechanism, and on development of methods for its prediction and studies on specific proteins, systems, and pathways. Allostery is an inherent property of biomacromolecules. Allostery can help explain dysfunction in disease, and it is increasingly brought into play in allosteric drug discovery.
AB - This thematic issue of Chemical Reviews focuses on allostery and protein Ensemble, including the populations of conformational states which constitute their physical foundation. The awareness of the immense significance of allostery in practically all biological processes, as assessed from the sheer statistics of studies centering on the concept, on elucidation of the mechanism, and on development of methods for its prediction and studies on specific proteins, systems, and pathways. Allostery is an inherent property of biomacromolecules. Allostery can help explain dysfunction in disease, and it is increasingly brought into play in allosteric drug discovery.
UR - http://www.scopus.com/inward/record.url?scp=84974555787&partnerID=8YFLogxK
U2 - 10.1021/acs.chemrev.6b00283
DO - 10.1021/acs.chemrev.6b00283
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AN - SCOPUS:84974555787
SN - 0009-2665
VL - 116
SP - 6263
EP - 6266
JO - Chemical Reviews
JF - Chemical Reviews
IS - 11
ER -