Introduction to Protein Ensembles and Allostery

Ruth Nussinov*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


This thematic issue of Chemical Reviews focuses on allostery and protein Ensemble, including the populations of conformational states which constitute their physical foundation. The awareness of the immense significance of allostery in practically all biological processes, as assessed from the sheer statistics of studies centering on the concept, on elucidation of the mechanism, and on development of methods for its prediction and studies on specific proteins, systems, and pathways. Allostery is an inherent property of biomacromolecules. Allostery can help explain dysfunction in disease, and it is increasingly brought into play in allosteric drug discovery.

Original languageEnglish
Pages (from-to)6263-6266
Number of pages4
JournalChemical Reviews
Issue number11
StatePublished - 8 Jun 2016


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