Intravitreal 5-fluorouracil in the prevention of post-traumatic vitreous proliferation

Isaak Avni; Michael Belkin; Alex Hercberg; Michael Blumenthal

doi:10.1159/000309337

Intravitreal 5-fluorouracil in the prevention of post-traumatic vitreous proliferation

Isaak Avni, Michael Belkin, Alex Hercberg, Michael Blumenthal^*

^*Corresponding author for this work

Sheba Medical Center at Tel Hashomer

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

We created double perforating injuries in both eyes of 24 rabbits. Into the vitreous cavity of one eye of each rabbit we injected 1 mg 5-fluorouracil (5-FU). After 2 months the eyes treated with 5-FU showed significantly less intraocular proliferation than the saline-treated control eyes.

Original language	English
Pages (from-to)	5-8
Number of pages	4
Journal	Ophthalmologica
Volume	188
Issue number	1
DOIs	https://doi.org/10.1159/000309337
State	Published - 1984
Externally published	Yes

Keywords

5-Fluorouracil
Cytotoxic agents
Eye injuries
Fibroblasts
Intraocular fibrosis
Intravitreal injections
Traction retinal detachment
Vitreous proliferation

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10.1159/000309337

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abstract = "We created double perforating injuries in both eyes of 24 rabbits. Into the vitreous cavity of one eye of each rabbit we injected 1 mg 5-fluorouracil (5-FU). After 2 months the eyes treated with 5-FU showed significantly less intraocular proliferation than the saline-treated control eyes.",

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KW - Fibroblasts

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Intravitreal 5-fluorouracil in the prevention of post-traumatic vitreous proliferation

Abstract

Keywords

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