Intravenous immunoglobulin treatment of pregnant patients with unexplained recurrent abortions

Arie Raziel*, Arie Herman, Ian Bukovsky, Eliahu Caspi, Raphael Ron-el

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

Abstract

Intravenous immunoglobulins, first given to recurrent aborters with anti-phospholipid syndrome, have been administered to unexplained aborters since 1986. They probably have immunomodulatory properties beyond supplying blocking antibodies. When pregnancy was confirmed, women were started with a loading dose which was repeated every 3-4 weeks until the second trimester. Dosages were empirical. Pregnancy rates ranged between 50 and 82%. The main maternal complications, i.e. allergic reactions and infections, were rare.

Original languageEnglish
Pages (from-to)711-715
Number of pages5
JournalHuman Reproduction
Volume11
Issue number4
DOIs
StatePublished - Apr 1996

Keywords

  • Habitual abortions
  • Immunotherapy
  • Intravenous immunoglobulins
  • Recurrent abortions
  • Unexplained abortions

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