Intravenous immunoglobulin therapy in a patient with lupus serositis and nephritis

M. Meissner, Y. Sherer, Y. Levy, H. Chwalinska-Sadowska, P. Langevitz, Y. Shoenfeld

Research output: Contribution to journalArticlepeer-review

Abstract

The use of intravenous immunoglobulin (IVIg) has been reported as an immunomodulating agent in several autoimmune diseases, including systemic lupus erythematosus (SLE). Herein we report a SLE patient with severe clinical presentation that included pericarditis, pleural effusion, nephrotic range proteinuria, leukopenia, and lymphopenia. The patient received one course of high-dose IVIg (2.8 g/kg body weight), and within a week of post-IVIg therapy, her condition significantly improved. One-month post-IVIg there were decreased proteinuria, elevated leukocytes and lymphocytes count, decrease in antinuclear and anti-dsDNA antibodies, and disappearance of pericarditis and pleuritis. This case demonstrates the efficacy of IVIg in severe SLE with various clinical manifestations.

Original languageEnglish
Pages (from-to)199-201
Number of pages3
JournalRheumatology International
Volume19
Issue number5
DOIs
StatePublished - 2000
Externally publishedYes

Keywords

  • Intravenous immunoglobulin
  • Pericarditis
  • Pleural effusion
  • Proteinuria
  • Systemic lupus erythematosus

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