TY - JOUR
T1 - Intrauterine irrigation with prostaglandin F2-α for management of severe postpartum hemorrhage
AU - Kupferminc, Michael J.
AU - Gull, Ilan
AU - Bar-am, Amiram
AU - Daniel, Yair
AU - Jaffa, Ariel
AU - Shenhav, Michael
AU - Lessing, Joseph B.
PY - 1998
Y1 - 1998
N2 - Background. Severe postpartum hemorrhage is a significant contributor to maternal morbidity and mortality. The use of prostaglandin F2-α to control severe postpartum hemorrhage may avert surgery for the control of bleeding. Methods. After ruling out the possibility of genital tract injuries, 18 patients with severe postpartum hemorrhage caused by uterine atony were enrolled in the study. None of the patients responded to treatment with oxytocin, methylergonovine, or uterine massage. A Foley catheter was introduced into the uterine cavity and the balloon was inflated with 5 ml sterile saline solution. The catheter was connected to an infusion line of 500 ml saline solution containing 20 mg prostaglandin F2-α. The solution was infused at a rate of 3-4 ml/minute for the first 10 min, and then reduced to 1 ml/minute for a period of 12-24 hours. Results. In 17 patients (94.4%) bleeding ceased within several minutes of initiation of intrauterine prostaglandin F2-α infusion, the uterus was firmly contracted and uterine bleeding did not recur. In one patient with placenta increta bleeding continued and hysterectomy was performed. None of the patients had any side effects. Conclusions. Intrauterine irrigation with low concentrations of prostaglandin F2-α is a simple, rapid and effective treatment for severe postpartum hemorrhage and facilitates constant and continuous hemostasis. Moreover, the minute dosage used eludes potentially complicating side effects.
AB - Background. Severe postpartum hemorrhage is a significant contributor to maternal morbidity and mortality. The use of prostaglandin F2-α to control severe postpartum hemorrhage may avert surgery for the control of bleeding. Methods. After ruling out the possibility of genital tract injuries, 18 patients with severe postpartum hemorrhage caused by uterine atony were enrolled in the study. None of the patients responded to treatment with oxytocin, methylergonovine, or uterine massage. A Foley catheter was introduced into the uterine cavity and the balloon was inflated with 5 ml sterile saline solution. The catheter was connected to an infusion line of 500 ml saline solution containing 20 mg prostaglandin F2-α. The solution was infused at a rate of 3-4 ml/minute for the first 10 min, and then reduced to 1 ml/minute for a period of 12-24 hours. Results. In 17 patients (94.4%) bleeding ceased within several minutes of initiation of intrauterine prostaglandin F2-α infusion, the uterus was firmly contracted and uterine bleeding did not recur. In one patient with placenta increta bleeding continued and hysterectomy was performed. None of the patients had any side effects. Conclusions. Intrauterine irrigation with low concentrations of prostaglandin F2-α is a simple, rapid and effective treatment for severe postpartum hemorrhage and facilitates constant and continuous hemostasis. Moreover, the minute dosage used eludes potentially complicating side effects.
KW - Intrauterine irrigation
KW - Prostaglandin F-α
KW - Severe postpartum hemorrhage
UR - http://www.scopus.com/inward/record.url?scp=0031778153&partnerID=8YFLogxK
U2 - 10.1080/j.1600-0412.1998.770513.x
DO - 10.1080/j.1600-0412.1998.770513.x
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AN - SCOPUS:0031778153
SN - 0001-6349
VL - 77
SP - 548
EP - 550
JO - Acta Obstetricia et Gynecologica Scandinavica
JF - Acta Obstetricia et Gynecologica Scandinavica
IS - 5
ER -