Intratumoural cyst formation in pituitary macroadenomas

Z. Ram*, M. Hadani, M. Berezin, G. Findler, A. Sahar, I. Shacked

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Twenty-one patients with various types of pituitary macroadenomas underwent hypophysectomy at the Chaim Sheba Medical Centre between 1985 to 1987. Intraoperative fine needle aspiration of the tumoural content was attempted prior to tumour excision. Although none of the patients had a history compatible with pituitary apoplexy, intratumoural fluid suggestive of a cyst within the tumour was found in 57% of the patients. Analysis of the hormones in the aspirated fluid revealed variable elevations in hormone levels, some reaching 3,000 times the equivalent plasma levels. Concomitant elevated levels of other pituitary hormones found in the cyst fluid support the concept of mixed secretory potential of pituitary adenomas, including the apparently non-functioning tumours. Six out of seven patients (86%) who received preoperative treatment with bromocriptine had an intratumoural cyst while only seven out of fourteen patients (50%) who were not treated with this drug prior to surgery had a cyst within the tumour. The implications of these observations on current theories concerning the pathophysiology of pituitary adenomas are discussed.

Original languageEnglish
Pages (from-to)56-61
Number of pages6
JournalActa Neurochirurgica
Issue number1-2
StatePublished - Mar 1989


  • Pituitary adenomas
  • bromocriptine
  • pituitary apoplexy
  • pituitary cyst
  • pituitary hormones
  • pituitary infarction


Dive into the research topics of 'Intratumoural cyst formation in pituitary macroadenomas'. Together they form a unique fingerprint.

Cite this