TY - JOUR
T1 - Intratubular germ cell neoplasia
T2 - Associated infertility and review of the diagnostic modalities
AU - Lifschitz-Mercer, Beatriz
AU - Elliott, David J.
AU - Schreiber-Bramante, Letizia
AU - Leider-Trejo, Leonor
AU - Eisenthal, Avi
AU - Maymon, Batia Bar Shira
PY - 2001
Y1 - 2001
N2 - The incidence of testicular neoplasia has increased, and its early detection has become a pressing clinical issue. The strong association between male subfertility and risk of testicular neoplasia is consistent with the existence of common pathogenetic factors. Most forms of testicular germ tumors are believed to stem from a common precursor, intratubular germ cell neoplasia (ITGCN), also known as testicular carcinoma in situ. Identification of ITGCN cells in testicular biopsies, however, is a diagnostic challenge and markers are sorely needed to assist in the accurate identification of the lesion.
AB - The incidence of testicular neoplasia has increased, and its early detection has become a pressing clinical issue. The strong association between male subfertility and risk of testicular neoplasia is consistent with the existence of common pathogenetic factors. Most forms of testicular germ tumors are believed to stem from a common precursor, intratubular germ cell neoplasia (ITGCN), also known as testicular carcinoma in situ. Identification of ITGCN cells in testicular biopsies, however, is a diagnostic challenge and markers are sorely needed to assist in the accurate identification of the lesion.
KW - Carcinoma in situ
KW - Diagnostic immunohistochemical markers
KW - RBM gene expression
KW - Testicular neoplasia
UR - http://www.scopus.com/inward/record.url?scp=0034930812&partnerID=8YFLogxK
U2 - 10.1177/106689690100900202
DO - 10.1177/106689690100900202
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AN - SCOPUS:0034930812
SN - 1066-8969
VL - 9
SP - 93
EP - 98
JO - International Journal of Surgical Pathology
JF - International Journal of Surgical Pathology
IS - 2
ER -
