@article{2788c1e8a2644cf898d9d60d6f0db182,
title = "Intrathecal treatment with dextrorphan or ketamine potently reduces pain-related behaviors in a rat model of peripheral mononeuropathy",
abstract = "The therapeutic effects of dextrorphan and ketamine, two non-competitive N-methyl-d-aspartate (NMDA) receptor antagonists, on neuropathic pain-related behaviors were examined in rats with peripheral mononeuropathy induced by loose ligation of the common sciatic nerve (chronic constrictive injury, CCI). Four daily intrathecal treatments (beginning 1 h after nerve ligation) with dextrorphan or ketamine (12.5-100 nmol) reliably attenuated hyperalgesia to radiant heat and spontaneous pain-related behaviors in CCI rats. Thermal hyperalgesia also was reduced in CCI rats receiving a single intrathecal treatment with either dextrorphan or ketamine (50 and 100 nmol for each compound) on day 3 after nerve ligation when thermal hyperalgesia was well developed. Since both dextrorphan and ketamine are currently utilized in other clinical applications, the results suggest a new therapeutic utility of these 'old' compounds in treatment of neuropathic pain syndromes resulting from peripheral nerve injury.",
keywords = "Dextrorphan, Hyperalgesia, Ketamine, NMDA receptor, Nerve injury, Neuropathic pain, Spontaneous pain",
author = "Jianren Mao and Price, \{Donald D.\} and Hayes, \{Ronald L.\} and Juan Lu and Mayer, \{David J.\} and Hanan Frenk",
note = "Funding Information: This work was supported by P.H.S. Grants NS 24009 and NS 21458.",
year = "1993",
month = mar,
day = "5",
doi = "10.1016/0006-8993(93)91368-3",
language = "אנגלית",
volume = "605",
pages = "164--168",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier B.V.",
number = "1",
}