Intrastriatal transplantation of mouse bone marrow-derived stem cells improves motor behavior in a mouse model of Parkinson's disease

D. Offen, Y. Barhum, Y. S. Levy, A. Burshtein, H. Panet, T. Cherlow, E. Melamed

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Strategies of cell therapy for the treatment of Parkinson's disease (PD) are focused on replacing damaged neurons with cells to restore or improve function that is impaired due to cell population damage. In our studies, we used mesenchymal stromal cells (MSCs) from mouse bone marrow. Following our novel neuronal differentiation method, we found that the basic cellular phenotype changed to cells with neural morphology that express specific markers including those characteristic for dopaminergic neurons, such as tyrosine hydroxylase (TH). Intrastriatal transplantation of the differentiated MSCs in 6-hydroxydopamine-lesioned mice led to marked reduction in the amphetamine-induced rotations. Immunohistological analysis of the mice brains four months post transplantation, demonstrated that most of the transplanted cells survived in the striatum and expressed TH. Some of the TH positive cells migrated toward the substantia nigra. In conclusion, transplantation of bone marrow derived stem cells differentiated to dopaminergic-like cells, successfully improved behavior in an animal model of PD suggesting an accessible source of cells that may be used for autotransplantation in patient with PD.

Original languageEnglish
Title of host publicationNeuropsychiatric Disorders An Integrative Approach
PublisherSpringer Wien
Pages133-143
Number of pages11
Edition72
ISBN (Print)9783211735732
DOIs
StatePublished - 2007

Publication series

NameJournal of Neural Transmission, Supplementa
Number72
ISSN (Print)0303-6995

Keywords

  • Multipotent mesenchymal stromal cells (MSCs)
  • Parkinson's disease (PD)
  • dopamine
  • dopaminergic neurons
  • stem cells

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