Intraprocedural invasive hemodynamic parameters as predictors of short- and long-term outcomes in patients undergoing transcatheter aortic valve replacement

Sarkis Kiramijyan, Edward Koifman, Marco A. Magalhaes, Itsik Ben-Dor, Romain Didier, Zachary D. Jerusalem, Sandeep Kumar, Arpi Tavil-Shatelyan, Toby Rogers, Arie Steinvil, Jiaxiang Gai, Rebecca Torguson, Lowell F. Satler, Augusto D. Pichard, Ron Waksman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Objective: Evaluation of invasive hemodynamic parameters as prognostic markers of mortality in patients undergoing TAVR. Background: The value of invasive intraprocedural hemodynamic evaluation of patients undergoing transcatheter aortic valve replacement is unclear. Methods: Consecutive patients who underwent transfemoral TAVR and had complete prospectively collected intraprocedural invasive hemodynamic parameters were retrospectively analyzed. Patients with alternative access, planned general anesthesia, or baseline ≥ moderate Tricuspid Regurgitation were excluded. Pre- and post-valve implant parameters included heart rate, systolic and diastolic blood pressures, cardiac output and index, pulmonary arterial systolic and diastolic pressures, transaortic pressure gradient and right atrial pressure. The primary end points were the association of the intraprocedural hemodynamic changes with all-cause mortality at 30 days and 1 year. Extensive Receiver Operating Characteristic analyses yielded dichotomized threshold of hemodynamic values in association with the binary outcome of mortality. Results: A total of 312 patients (52% male, mean age 83 years) were evaluated. A significant association with 30-day and 1-year mortality was found between intraprocedural post-valve implant cardiac index < 1.9 vs. ≥ 1.9 L/min/m 2 (Log-ranked p = 0.0286 and p = 0.0432, respectively). Four subgroups with pre- and post-valve implant CI changes (L/min/m 2 ) were compared: [1] pre < 1.9, stable_post < 1.9; [2] pre < 1.9, improved_post ≥ 1.9; [3] pre ≥ 1.9, stable_post ≥ 1.9; and [4] pre ≥ 1.9, worsened_post < 1.9. Group 1 (lower CI with no post-valve improvement) had the worst survival, and Group 3 (higher CI and stable post-valve) had the best survival at 1-year follow-up (Log-ranked p = 0.0089). Conclusions: In patients with severe aortic stenosis undergoing TAVR, invasive monitoring can assess for hemodynamic prognostic markers of survival.

Original languageEnglish
Pages (from-to)257-262
Number of pages6
JournalCardiovascular Revascularization Medicine
Issue number3
StatePublished - Apr 2018
Externally publishedYes


FundersFunder number
Edwards Lifesciences
Chiesi Farmaceutici
Boston Scientific Corporation
Abbott Vascular
Biosensors International Group


    • Aortic stenosis
    • Cardiac output
    • Hemodynamics
    • Transcatheter aortic valve replacement


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